A Case of Cutaneous Leishmaniasis with Mucosal Involvement in the Northern United States

J Emerg Med. 2024 Jun;66(6):e690-e693. doi: 10.1016/j.jemermed.2024.01.015. Epub 2024 Jan 26.

Abstract

Background: Cutaneous leishmaniasis (CL) is a vector-borne parasitic infection endemic to many sub-tropical regions worldwide. In the Americas, Leishmania braziliensis is responsible for most reported CL cases. Variable symptom presentation and susceptibility to secondary infection make diagnosing CL a difficult proposition for physicians who may not encounter cases frequently.

Case report: We present the case of a 50-year-old man with multiple progressive lesions, diagnosed initially as a bacterial infection, who presented to a North American emergency department after several unsuccessful trials of antibiotic therapy. Eventually, polymerase chain reaction testing of a wound biopsy sample confirmed the presence of L. braziliensis. After a complicated course, the patient's infection resolved after tailored antiparasitic therapy. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: This case highlights the need to include travel history in the evaluation of atypical dermatologic infections.

Keywords: chronic lesion; leishmaniasis; mucocutaneous; nonendemic; treatment failure.

Publication types

  • Case Reports

MeSH terms

  • Antiprotozoal Agents / therapeutic use
  • Humans
  • Leishmania braziliensis / pathogenicity
  • Leishmaniasis, Cutaneous* / diagnosis
  • Leishmaniasis, Cutaneous* / drug therapy
  • Male
  • Middle Aged
  • United States

Substances

  • Antiprotozoal Agents