Vitamin D and immune system

Geoffrey Brown; Aleksandra Marchwicka; Ewa Marcinkowska

doi:10.1016/bs.afnr.2023.12.001

Vitamin D and immune system

Adv Food Nutr Res. 2024:109:1-41. doi: 10.1016/bs.afnr.2023.12.001. Epub 2024 Mar 6.

Authors

Geoffrey Brown¹, Aleksandra Marchwicka², Ewa Marcinkowska³

Affiliations

¹ School of Biomedical Sciences, Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
² Department of Protein Biotechnology, Faculty of Biotechnology, University of Wrocław, Wrocław, Poland.
³ Department of Protein Biotechnology, Faculty of Biotechnology, University of Wrocław, Wrocław, Poland. Electronic address: ema@cs.uni.wroc.pl.

PMID: 38777411
DOI: 10.1016/bs.afnr.2023.12.001

Abstract

The active metabolite of vitamin D 1,25(OH)₂D is well known for its role in regulating calcium-phosphate homeostasis of the human body. However, the immunomodulating activity of 1,25(OH)₂D has been known for many years. There are numerous reports correlating low vitamin D levels in blood serum with the onset of autoimmune diseases and with the severe course of acute infections. In this chapter, we address the role of 1,25(OH)₂D in these diseases, and we discuss the possible mechanisms of action of 1,25(OH)₂D in immune cells.

Keywords: 1; 25(OH)(2)D; Acute infections; Autoimmune diseases; Complement system; Dendritic cells; Immune system; Macrophages; Vitamin D receptor.

Publication types

Review

MeSH terms

Autoimmune Diseases / immunology
Humans
Immune System*
Vitamin D Deficiency
Vitamin D*

Substances

Vitamin D