Pleural Spindle Cell Sarcoma on 68Ga-DOTA-FAPI-04 PET/CT and 18F-FDG PET/CT: A Rare Case

Yan Cui; Xin Zhou; Nan Li

doi:10.1097/RLU.0000000000005274

Pleural Spindle Cell Sarcoma on 68Ga-DOTA-FAPI-04 PET/CT and 18F-FDG PET/CT: A Rare Case

Clin Nucl Med. 2024 May 23. doi: 10.1097/RLU.0000000000005274. Online ahead of print.

Authors

Yan Cui¹, Xin Zhou, Nan Li

Affiliation

¹ From the Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China.

PMID: 38778462
DOI: 10.1097/RLU.0000000000005274

Abstract

A 67-year-old woman with pleural mass underwent 18F-FDG PET/CT, suspected of malignant pleural tumor with intense 18F-FDG uptake. Then she underwent 68Ga-DOTA-FAPI-04 PET/CT for staging, which showed similar uptake in pleural lesions and opposite uptake pattern in mediastinal and hilar lymph nodes. Finally, she was diagnosed with spindle cell sarcoma (G2) by histopathology. After 1 cycle chemotherapy, the pleural lesions progressed, while mediastinal lymph nodes shrunk. Half a month later, the patient died due to rapid disease progression. This case indicates that 68Ga-FAPI PET/CT might be a promising new tool in diagnosis and staging of pleural spindle cell sarcoma.