Elevated Cardiac Troponin I Level associated to Cardiac Dysfunction in Burned Patients

Carolina Segura; George Golovko; Isabel Obias; Suhaib Shah; Amina El Ayadi; Steven Wolf; Juquan Song

doi:10.1093/jbcr/irae086

Elevated Cardiac Troponin I Level associated to Cardiac Dysfunction in Burned Patients

J Burn Care Res. 2024 May 23:irae086. doi: 10.1093/jbcr/irae086. Online ahead of print.

Authors

Carolina Segura¹, George Golovko², Isabel Obias¹, Suhaib Shah¹, Amina El Ayadi³, Steven Wolf³, Juquan Song³

Affiliations

¹ Department of Surgery, University of Texas Medical Branch, Galveston, USA.
² Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, USA.
³ Department of Pharmacology, University of Texas Medical Branch, Galveston, USA.

PMID: 38778576
DOI: 10.1093/jbcr/irae086

Abstract

Severely burned patients often developed cardiac dysfunction and heart failure. The purpose of this retrospective study is to evaluate the role of Cardiac Troponin I (cTI) and its association to patients with burns. Patients deidentified data were collected from a national database in May 2023. Adult burn patients who had cTnI lab counted were enrolled in this study. Patients were grouped by the cTnI mean level within 72 hours including patients with elevated cTnI levels at >0.3 ng/mL (n= 2188 patients), and patients with non-elevated cTnI level (< 0.04 ng/mL) (n= 3200). The cohorts were further stratified by less than 20% TBSA mild burn population and >20% TBSA severe burn population to replicate the severity of burns. The 30-days incidences of acute myocardial infarction (MI), sepsis, and mortality were investigated after the cohorts were propensity matching balanced. The odds ratios (ORs) with 95%CI for MI were (9.829/7.081-13.645), sepsis (1.527/1.269-1.959) and mortality (2.586/2.110- 3.170) respectively (p<0.05). The groups that were further stratified into mild burn and severe burn had the following results: The mild burn ORs and 95% CI for MI was (6.237/3.986-9.785), sepsis (1.603/1.132-2.270), and mortality was (2.298/1.629-3.242). The severe burn cohort had ORs and 95% CI for MI (3.145/1.469-6.732), sepsis (0.993/0.555-1.777), mortality (2.934/1.924-4.475). In conclusion, the patients with earlier elevated cTnI level had worse outcomes of MI and mortality in both severe and mild burns.

Keywords: burns; cardiac troponin I; mortality; myocardial infarction; sepsis.

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