[Multi-omics research progress in early-onset colorectal cancer]

Zhonghua Wei Chang Wai Ke Za Zhi. 2024 May 25;27(5):447-451. doi: 10.3760/cma.j.cn441530-20240205-00058.
[Article in Chinese]

Abstract

Globally, the incidence of early-onset colorectal cancer (EOCRC) among individuals younger than 50 is escalating. Compared to late-onset colorectal cancer, EOCRC exhibits distinct clinical, pathological, and molecular features, with a higher prevalence in the left colon and rectum. However, the occurrence and development of EOCRC is a multi-factor and multi-stage evolution process, which is the result of the mutual effect of environmental, genetic and biological factors, and involves the multi-level regulation mechanism of other organisms. With the development and improvement of high-throughput sequencing technology, the application of multi-omics analysis has become an important development direction to resolve the pathogenesis of complex diseases and individualized treatment plans. This article aims to review the research progress of EOCRC at the multi-omics level, providing a theoretical foundation for earlier diagnosis and more precise treatment of this diseases.

全球范围内,50岁以下的早发性结直肠癌(EOCRC)的发病率不断上升。与晚发性结直肠癌相比,EOCRC具有不同的临床、病理和分子特征,且多发于左半结肠和直肠。然而,EOCRC的发生、发展是一个多因素、多阶段的演变过程,是环境、遗传和生物等因素共同作用的结果,涉及生命体多层次的调控机制。近年来,随着高通量测序技术的快速发展和完善,利用多层次多组学技术的整合分析已经成为解析复杂疾病发病机制和个体化治疗方案的重要发展方向。本文将对EOCRC在多组学层面的研究进行综述,以期为结直肠癌的早期诊断和精准治疗提供重要科学依据。.

Publication types

  • Review
  • English Abstract

MeSH terms

  • Age of Onset
  • Colorectal Neoplasms* / diagnosis
  • Colorectal Neoplasms* / genetics
  • Genomics
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Metabolomics
  • Multiomics
  • Proteomics / methods