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. 2024 Aug;31(8):805-816.
doi: 10.1111/acem.14932. Epub 2024 May 23.

2023 Society for Academic Emergency Medicine Consensus Conference on Precision Emergency Medicine: Development of a policy-relevant, patient-centered research agenda

Matthew Strehlow  1 , Michael A Gisondi  1 , Holly Caretta-Weyer  1 , Felix Ankel  2 , Alexandria Brackett  3 , Pawan Brar  1 , Teresa M Chan  4   5 , Adrene Garabedian  1 , Bridget Gunn  6 , Eric Isaacs  7 , Megan von Isenburg  8 , Angela Jarman  9 , Damon Kuehl  10 , Alexander T Limkakeng  8 , Melis Lydston  11 , Alyson McGregor  12 , Ava Pierce  13 , Maria C Raven  7 , Rama A Salhi  14 , Christopher Stave  1 , Josephine Tan  7 , Richard Andrew Taylor  15 , Hong-Nei Wong  16 , Maame Yaa A B Yiadom  1 , Kori S Zachrison  14 , Jody Vogel  1
Affiliations

2023 Society for Academic Emergency Medicine Consensus Conference on Precision Emergency Medicine: Development of a policy-relevant, patient-centered research agenda

Matthew Strehlow et al. Acad Emerg Med. 2024 Aug.

Abstract

Objectives: Precision medicine is data-driven health care tailored to individual patients based on their unique attributes, including biologic profiles, disease expressions, local environments, and socioeconomic conditions. Emergency medicine (EM) has been peripheral to the precision medicine discourse, lacking both a unified definition of precision medicine and a clear research agenda. We convened a national consensus conference to build a shared mental model and develop a research agenda for precision EM.

Methods: We held a conference to (1) define precision EM, (2) develop an evidence-based research agenda, and (3) identify educational gaps for current and future EM clinicians. Nine preconference workgroups (biomedical ethics, data science, health professions education, health care delivery and access, informatics, omics, population health, sex and gender, and technology and digital tools), comprising 84 individuals, garnered expert opinion, reviewed relevant literature, engaged with patients, and developed key research questions. During the conference, each workgroup shared how they defined precision EM within their domain, presented relevant conceptual frameworks, and engaged a broad set of stakeholders to refine precision EM research questions using a multistage consensus-building process.

Results: A total of 217 individuals participated in this initiative, of whom 115 were conference-day attendees. Consensus-building activities yielded a definition of precision EM and key research questions that comprised a new 10-year precision EM research agenda. The consensus process revealed three themes: (1) preeminence of data, (2) interconnectedness of research questions across domains, and (3) promises and pitfalls of advances in health technology and data science/artificial intelligence. The Health Professions Education Workgroup identified educational gaps in precision EM and discussed a training roadmap for the specialty.

Conclusions: A research agenda for precision EM, developed with extensive stakeholder input, recognizes the potential and challenges of precision EM. Comprehensive clinician training in this field is essential to advance EM in this domain.

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Conflict of interest statement

MS, MAG, and MCH are Consensus Conference co-chairs and received 2% FTE salary from the SAEM conference budget. There were no financial incentives based on conference registrations or evaluations.

MG is supported by grant funding to Stanford from The Agency for Healthcare Quality and Research (AHRQ 1R13HS029275-01).

TMC reports grant support to McMaster University from the PSI Foundation and Medical Council of Canada, and received payment from the Association of American Medical Colleges for writing part of the manuscript.

AJ reports grant funding to University of California, Davis, from NIH for investigator-initiated research.

DK has received money from Cook Medical for providing staff educational materials and from Brainbox, Rebion, Philips, and Veralox for investigator-initiated research. He also serves on the scientific advisory boards of Brainbox and Rebion, and receives stock options as compensation.

ATL reports grant funding to Duke University for investigator-initiated research from Roche Diagnostics, Inc., Abbott Laboratories, Quidel Inc., Brainbox Inc., Forest Devices, Inc., Becton Dickenson, SENSE Neuro Diagnostics, Ophirex, Inc., and Jiaxing Wisetest Biotech, Co.

AP is a SAEM Board of Directors Member at Large and receives support from the SAEM Foundation/Academy for Diversity and Inclusion in Emergency Medicine and the National Heart, Lung and Blood Institute.

All other authors declare no conflicts of interest.

Figures

Figure 1:
Figure 1:
Precision Emergency Medicine Definition and Workgroups
Figure 2:
Figure 2:. Workgroups Literature Review Methodologies.
For domains in which the initial literature review produced adequate literature, scoping or rapid reviews were conducted. The purpose of a scoping review is to summarize the body of literature, identify key topics and concepts, and describe existing research efforts and directions. A rapid review uses a simplified but systematic approach to identify, select, and analyze data from the literature. For domains in which the initial review produced insufficient literature, the workgroups conducted a state-of-the-art review, which provides an overall summary of the latest knowledge in the domain, or a foresight review, which focuses on emerging trends and future directions within the domain.
Figure 3:
Figure 3:
Consensus Conference Agenda
See this image and copyright information in PMC

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