LncRNA TINCR: an irreplaceable biological target in human malignancies

Dengke Jia; Yaping He; Yawu Zhang

doi:10.2174/0109298673290217240513093711

LncRNA TINCR: an irreplaceable biological target in human malignancies

Curr Med Chem. 2024 May 22. doi: 10.2174/0109298673290217240513093711. Online ahead of print.

Authors

Dengke Jia¹, Yaping He², Yawu Zhang^{1

3

4}

Affiliations

¹ Lanzhou University Second Clinical Medical College, Lanzhou University, Lanzhou 730000, China.
² Gansu University of Chinese Medicine Lanzhou 730000, China.
³ Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730000, China.
⁴ Hepato--Biliary-Pancreatic Institute, Lanzhou University Second Hospital, Lanzhou 730000, China.

PMID: 38779727
DOI: 10.2174/0109298673290217240513093711

Abstract

Background: Currently, malignant tumors of the digestive system tend to affect younger people, which has brought a catastrophic burden to people around the world. lncRNA has gained considerable attention because of its importance in the early diagnosis and treatment of tumors. In addition, since terminal differentiation-induced ncRNA ( abbreviated as TINCR )was reported in a Nature article, it has received focus on targeted therapy of tumors, especially in digestive system malignant tumors. This review aims to reveal and summarize its important molecular mechanisms in digestive system malignancies.

Method: In this review, relevant research involving the relationship between TINCR and digestive system malignancies are collected through systematic retrieval of PubMed.

Results: TINCR is expressed bidirectionally in malignant tumors of the digestive system. TINCR functions primarily as a ceRNA in digestive system tumors, and TINCR also functions at the transcriptional level.

Conclusion: lncRNA TINCR has the potential to become a novel biomolecular marker of the digestive system.

Keywords: LncRNA; TINCR; biomolecular marker; diagnosis; digestive system; malignant tumor; metabolism; therapeutic target.