Ye-1, a monoclonal antibody that cross-reacts with HLA-B27 lymphoblastoid cell lines and an arthritis causing bacteria

Clin Exp Immunol. 1985 Sep;61(3):503-8.


A monoclonal antibody, Ye-1, was generated by immunizing BALB/c mice with Yersinia enterocolitica. This antibody also reacted with all of 12 B27 positive lymphoblastoid cell lines, but only four of 31 B27 negative ones. Three of the four reactive B27 negative cell lines were B7 positive. A B27 positive cell line which has lost the B27 expression because of experimentally-induced mutation became unreactive with the Ye-1. These findings support the possibility that there is cross-reactivity between HLA-B27 antigens and Y. enterocolitica.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology*
  • Antigens, Bacterial / immunology
  • Arthritis, Infectious / immunology*
  • Arthritis, Reactive / immunology*
  • Cell Line
  • Cross Reactions
  • Enzyme-Linked Immunosorbent Assay
  • HLA Antigens / analysis
  • HLA Antigens / immunology*
  • HLA-B27 Antigen
  • Humans
  • Leukemia, Experimental / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Yersinia enterocolitica / immunology*


  • Antibodies, Monoclonal
  • Antigens, Bacterial
  • HLA Antigens
  • HLA-B27 Antigen