FosA8-producing E. coli ST131: clinical cases in Italy, February 2023

Euro Surveill. 2024 May;29(21):2400276. doi: 10.2807/1560-7917.ES.2024.29.21.2400276.

Abstract

Fosfomycin-resistant FosA8-producing Enterobacterales are uncommon strains with extremely low incidence in Europe, based on only three reports in the literature. We detected FosA8-producing Escherichia coli ST131 in clinical isolates from two patients admitted in February 2023 to a rehabilitation unit in Italy. The occurrence of rare fosA-like genes in the high-risk clone ST131 is of clinical relevance. The dissemination of FosA-producing E. coli, although still at low levels, should be continuously monitored.

Keywords: E. coli ST131; FosA8; Fosfomycin; Fosfomycin resistance,.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents* / pharmacology
  • Anti-Bacterial Agents* / therapeutic use
  • Drug Resistance, Bacterial
  • Escherichia coli Infections* / epidemiology
  • Escherichia coli Infections* / microbiology
  • Escherichia coli* / drug effects
  • Escherichia coli* / genetics
  • Escherichia coli* / isolation & purification
  • Female
  • Fosfomycin / pharmacology
  • Fosfomycin / therapeutic use
  • Humans
  • Italy / epidemiology
  • Male
  • Microbial Sensitivity Tests
  • Multilocus Sequence Typing
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism

Substances

  • Anti-Bacterial Agents
  • Fosfomycin
  • beta-Lactamases