Reverse transcription of HIV-1 2-LTR circle transcripts does frequently cause 3'-polypurine tract mutations implicated in dolutegravir resistance

J Virol. 2024 Jun 13;98(6):e0033524. doi: 10.1128/jvi.00335-24. Epub 2024 May 24.
No abstract available

Keywords: HIV-1; dolutegravir; drug resistance mechanisms; drug-resistance evolution.

Publication types

  • Letter

MeSH terms

  • Drug Resistance, Viral* / genetics
  • HIV Infections* / drug therapy
  • HIV Infections* / virology
  • HIV Integrase Inhibitors / pharmacology
  • HIV-1* / drug effects
  • HIV-1* / genetics
  • Heterocyclic Compounds, 3-Ring* / pharmacology
  • Humans
  • Mutation*
  • Oxazines* / pharmacology
  • Piperazines* / pharmacology
  • Pyridones*
  • Reverse Transcription

Substances

  • dolutegravir
  • Heterocyclic Compounds, 3-Ring
  • Pyridones
  • Piperazines
  • Oxazines
  • HIV Integrase Inhibitors