Abstract
Congenital complete heart block is closely associated with the presence of anti-Ro (SS-A) autoantibodies. Quantitative solid-phase assays for Ro (SS-A) autoantigen and autoantibody have established the presence of Ro (SS-A) in cardiac tissues and have been used to evaluate an informative pedigree. The propositus we describe here had complete congenital heart block and showed anti-Ro (SS-A) binding of 13-fold less than his normal HLA-identical twin sister. Both had identical titers of antinuclear antibody. These data support the hypothesis that anti-Ro (SS-A) may be directly involved in the pathogenesis of congenital complete heart block.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Antibodies, Antinuclear / analysis
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Antigens / analysis*
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Autoantigens / analysis*
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Diseases in Twins*
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Enzyme-Linked Immunosorbent Assay
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Female
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Fetus / immunology
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Heart Block / complications
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Heart Block / congenital*
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Heart Block / immunology
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Humans
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Infant, Newborn
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Male
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Myocardium / immunology
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Pedigree
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Precipitin Tests
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Pregnancy
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Prenatal Diagnosis
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RNA, Small Cytoplasmic*
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Ribonucleoproteins*
Substances
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Antibodies, Antinuclear
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Antigens
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Autoantigens
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RNA, Small Cytoplasmic
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RO60 protein, human
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Ribonucleoproteins
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SS-A antigen