Calcitonin gene-related peptide: brain and spinal action on intestinal motility

Peptides. Nov-Dec 1985;6(6):1167-71. doi: 10.1016/0196-9781(85)90445-0.

Abstract

The effects of intracerebroventricular (ICV) and intrathecal (IT) administration of calcitonin gene-related peptide (CGRP) on intestinal motility were examined in conscious rats chronically fitted with intraparietal electrodes in the duodeno-jejunum and a cannula in a cerebral lateral ventricle or catheter in the subarachnoid space. ICV administration of CGRP (0.5-10 micrograms) restores the fasted pattern of intestinal motility in fed rats in a dose-related manner. Intrathecal administration of CGRP or calcitonin also induces fasted pattern but after a 30 min delay. These effects persisted after transection of the spinal cord and no change in intestinal motility appeared after intravenous administration of CGRP at a dose effective when given IT. This study suggests that CGRP, as calcitonin, has a neuromodulatory role in the control of intestinal motility at both brain and spinal cord levels.

MeSH terms

  • Animals
  • Brain / physiology*
  • Calcitonin / pharmacology
  • Calcitonin Gene-Related Peptide
  • Cerebral Ventricles / drug effects
  • Cerebral Ventricles / physiology*
  • Duodenum / drug effects
  • Duodenum / physiology
  • Electric Conductivity / drug effects
  • Gastrointestinal Motility / drug effects*
  • Injections, Intraventricular
  • Injections, Spinal
  • Jejunum / drug effects
  • Jejunum / physiology
  • Male
  • Nerve Tissue Proteins / administration & dosage
  • Nerve Tissue Proteins / pharmacology*
  • Rats
  • Rats, Inbred Strains
  • Spinal Cord / physiology*
  • Vasodilator Agents / pharmacology*

Substances

  • Nerve Tissue Proteins
  • Vasodilator Agents
  • Calcitonin
  • Calcitonin Gene-Related Peptide