The Lebanese percreta group: A retrospective cohort study of both radical and conservative management outcomes of abnormally invasive placenta

Muhieddine Seoud; Rabih Chahine; Wissam Arab; Iman Jaafar; Malak Moubarak; Nadine El Kassis; Reem Abdallah; Mohamad K Ramadan; Malek Nassar; Anwar Nassar; Eliane Nasser Ayoub; David Atallah

doi:10.1002/ijgo.15701

The Lebanese percreta group: A retrospective cohort study of both radical and conservative management outcomes of abnormally invasive placenta

Int J Gynaecol Obstet. 2024 May 27. doi: 10.1002/ijgo.15701. Online ahead of print.

Affiliations

¹ Department of Obstetrics and Gynecology, American University of Beirut Medical Center (AUBMC), Beirut, Lebanon.
² Department of Obstetrics and Gynecology, Rafic Hariri University Hospital (RHUH), Beirut, Lebanon.
³ Department of Obstetrics and Gynecology, Hotel-Dieu de France (HDF) University Hospital, Saint-Joseph University, Beirut, Lebanon.
⁴ Intensive Care and Anesthesiology Department, Hotel-Dieu de France (HDF) University Hospital, Saint-Joseph University, Beirut, Lebanon.

PMID: 38798144
DOI: 10.1002/ijgo.15701

Abstract

Objective: The aim of the present study was to illustrate the outcomes of abnormally invasive placenta (AIP) cases managed in three leading centers in Lebanon.

Methods: We conducted a retrospective multicenter cohort study. Patients managed conservatively (cesarean delivery with successful placental separation) or radically (cesarean hysterectomy) were included in the study. Data included patient characteristics, surgical outcomes (blood loss, operative time, transfusion, partial bladder resection), maternal outcomes (death, length of stay, ICU admission, postoperative hemoglobin level) and neonatal outcomes (Apgar score, neonatal weight, admission to neonatal intensive care unit, neonatal death).

Results: The study included 189 patients. In the radical treatment subgroup (141/189), patients were para 3 and delivered at 34 4/7 weeks in average, bled 1.5 L and were transfused with three packed red blood cells, with operative time averaging 160 min. A total of 36% were admitted to the ICU and patients stayed on average for 1 week despite partial bladder resection in 19% of cases. Unscheduled radical delivery occurred at a lower gestational age, was associated with more blood loss, higher rate and volume of transfusion, and risk of maternal and neonatal death. In addition, patients delivered in an unscheduled fashion experienced higher rates of partial bladder resection and longer interventions. In the conservative treatment subgroup, on average patients were para 2 and delivered at 36 weeks, bled 800 mL on average with low rates of transfusion (35%) and ICU admission (22.9%). With regard to neonatal outcomes, the average neonatal birth weight was 2.4 kg in the radical subgroup and 2.5 kg in the conservative subgroup. Neonatal death occurred in 5.4% of cases requiring radical management while it occurred in 2% of patients treated conservatively.

Conclusion: Through their multidisciplinary approach, the three centers demonstrated that management of AIP in Lebanon has led to excellent outcomes with no maternal mortality occurring in scheduled radical treatment. By comparison of the three leading centers, pitfalls in each center were identified and addressed.

Keywords: abnormally invasive placenta; bladder resection; conservative management; death; intensive care; scheduled delivery; transfusion; unscheduled delivery.