Challenges and Uncertainties in the Diagnosis of Cardiac Amyloidosis: A Case Report

Cureus. 2024 May 23;16(5):e60954. doi: 10.7759/cureus.60954. eCollection 2024 May.

Abstract

Amyloidosis is the condition when starch-like misfolded proteins form insoluble fibrils that deposit in tissues and cause dysfunction. Cardiac amyloidosis occurs due to the deposition of amyloid fibrils at the cardiac level and is an important cause of heart failure. This case reveals a patient with significant heart failure and arrhythmia, which later on turned out to be caused by cardiac amyloidosis. While regarded as a rare disease in practice, in retrospect, there are a lot of signs and imaging indicators, particularly in echocardiography that warrant an investigation of cardiac amyloidosis. In this case review, red flags in echocardiography that should endorse further testing for underlying cardiac amyloidosis are highlighted.

Keywords: al cardiac amyloidosis; atrial fibrillation cardiac amyloidosis; chemotherapy cardiac amyloidosis; delayed diagnosis cardiac amyloidosis; diagnostic criteria of cardiac amyloidosis; echocardiography findings cardiac amyloidosis; heart failure cardiac amyloidosis; heart transplant cardiac amyloidosis; imaging in cardiac amyloidosis; speckled tracking echocardiography.

Publication types

  • Case Reports