Itraconazole Oral Solution for Infantile Complicated Hemangioma with Double Lesions on the Skin and One Inside the Liver

Clin Cosmet Investig Dermatol. 2024 May 23:17:1217-1226. doi: 10.2147/CCID.S462665. eCollection 2024.

Abstract

An infantile hemangioma is a congenital benign tumor formed by the proliferation of vascular cells during the embryonic stage. It is more common in the skin but can also occur in the mucous membranes, liver, brain and muscle. Hepatic hemangioma appears to be a benign tumor; however, it may lead to poor outcomes because of severe complications, such as high-output cardiac failure. The main treatment of hepatic hemangioma in infants is oral drugs, such as propranolol and glucocorticoids, but the clinical response is not always satisfactory. We describe a rare case of a 2-month-old boy who presented with infantile cutaneous and hepatic hemangiomas. By using dermoscopy and observations of the abdominal color Doppler ultrasound, after 9 months of oral treatment with itraconazole solution, the infantile cutaneous hemangioma complicated with hepatic hemangioma was eventually cured. There was no liver or kidney function damage during the whole treatment period. Itraconazole oral solution for the treatment of infantile cutaneous hemangioma complicated with hepatic hemangioma showed good efficacy, compliance, and safety in this case.

Keywords: color ultrasonic; cutaneous; dermoscopy; hepatic; infantile hemangioma; itraconazole oral solution.

Publication types

  • Case Reports

Grants and funding

This work was supported in part by the Sichuan Science and Technology Program (Grant 2020YFS0194), the National Natural Science Foundation of China (Grant 81472539), 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University, and HX-Academician project (HXYS19003), West China Hospital, Sichuan University.