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. 2024 Spring;15(2):340-346.
doi: 10.22088/cjim.15.2.340.

Effect of selenium on anti-Tg antibody in patients with autoimmune hypothyroidism: A randomized controlled trial

Mina AkbariRad  1 , Zahra Mazloum Khorasani  2 , Behnam Beizae  3 , Hossein Ayatollahi  4 , Maryam Emadzadeh  5 , Mehrdad Sarabi  6 , Nikoo Saeedi  7 , Negar Nekooei  6
Affiliations

Effect of selenium on anti-Tg antibody in patients with autoimmune hypothyroidism: A randomized controlled trial

Mina AkbariRad et al. Caspian J Intern Med. 2024 Spring.

Abstract

Background: The current study intends to assess the impact of oral selenium intake on anti-Tg antibody in individuals with autoimmune hypothyroidism.

Methods: In this double-blinded randomized controlled trial, two groups of 72 autoimmune hypothyroid patients were randomly assigned; one group received levothyroxine (LT4) and oral selenium and the other group was given placebo with LT4. Anti-Tg antibody, free T4, anti-TPO antibody, and TSH were identified in both groups before the treatment and also 3 months after treatment and analysis of data was done by SPSS software.

Results: After the intervention, the average amount of anti-Tg antibody decreased in both of the groups, and this decrease was noticeably greater in the intervention group (P = 0.03). In the intervention group, the TSH level decreased after the intervention (p < 0.05), and the free T4 level increased after the intervention (p < 0.05); the changes in these two variables were statistically significant.

Conclusion: Consumption of selenium, compared to placebo, in patients with autoimmune hypothyroidism drastically reduces the level of anti-Tg antibody, and it significantly increases the free T4 level. Also, there is a greater decrease in the level of TSH compared to the control group.

Keywords: Anti-Tg antibody; Autoimmune hypothyroidism; Selenium.

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Conflict of interest statement

The authors have no declared conflicts of interest pertaining to this publication’s content. The Iranian Registry of Clinical Trials received registration for this study with the IRCT Number: IRCT20180211038689N1.

Figures

Figure 1
Figure 1
The flowchart of included patients
See this image and copyright information in PMC

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