Testosterone therapy over 60 months improves aging male symptoms scores in all men with adult-onset testosterone deficiency

Aging Male. 2024 Dec;27(1):2357548. doi: 10.1080/13685538.2024.2357548. Epub 2024 May 29.


Objective: We evaluated change (Δ) in AMSS in men with adult-onset testosterone deficiency (TD) on/not on testosterone undecanoate (TU) by analysing a registry of men with adult-onset TD.

Methods: Analyses were performed using non-parametric statistics to determine ΔAMSS at 6-12 monthly intervals in men on/not on TU and movement in AMSS. Factors predicting ΔAMSS were established via linear/multiple regression.

Results: TU was significantly associated with lower AMSS values compared with that at baseline/prior assessment during the initial 42 months treatment; 259 of the 260 men showed improvement. In the 361 men not on TU, AMSS values increased during 60 months of follow-up compared with that at baseline/prior assessment; improvement after 60 months was evident in 1 man, whilst AMSS remained the same or worsened in 213 and 147 men, respectively. In men on TU, baseline AMSS was inversely associated with ΔAMSS (R2 = 0.97), with no other factors reaching significance. Baseline AMSS, age, serum total testosterone (TT), waist circumference (WC), and diastolic blood pressure (BP) were associated with ΔAMSS in men not on TU.

Discussion: We show that TU was associated with lower AMSS in men with adult-onset TD whilst non-treatment led to increased values. Baseline AMSS values inversely predicted ΔAMSS in both groups.

Keywords: Aging male symptoms score; Wilder Effect; adult-onset hypogonadism; metabolic syndrome; testosterone therapy.

MeSH terms

  • Adult
  • Aged
  • Aging / physiology
  • Hormone Replacement Therapy / methods
  • Humans
  • Hypogonadism / blood
  • Hypogonadism / drug therapy
  • Male
  • Middle Aged
  • Registries
  • Testosterone* / administration & dosage
  • Testosterone* / analogs & derivatives
  • Testosterone* / blood
  • Testosterone* / deficiency
  • Testosterone* / therapeutic use


  • Testosterone
  • testosterone undecanoate