Trimipramine in physical illness with depression

J Clin Psychiatry. 1985 Feb;46(2 Pt 2):4-8.


To assess whether tricyclic antidepressants are useful in patients with a serious physical disorder who develop symptoms of major depression, 42 medically ill outpatients who met RDC criteria for endogenous major depression and had a Raskin depression score of at least 7 were studied. The patients were randomly assigned to a 6-week trial of trimipramine or placebo under double-blind conditions. In the placebo group, depressive symptoms improved when the physical disorder improved; in the trimipramine group, improvement was seen in the depressive symptoms even when there was no concomitant improvement in physical condition.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjustment Disorders / complications
  • Adjustment Disorders / drug therapy
  • Adjustment Disorders / psychology
  • Ambulatory Care
  • Clinical Trials as Topic
  • Depressive Disorder / drug therapy*
  • Depressive Disorder / etiology
  • Depressive Disorder / psychology
  • Dibenzazepines / therapeutic use*
  • Disease / complications*
  • Disease / psychology
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Outcome and Process Assessment, Health Care
  • Personality Inventory
  • Placebos
  • Psychiatric Status Rating Scales
  • Psychotherapy, Brief
  • Trimipramine / therapeutic use*


  • Dibenzazepines
  • Placebos
  • Trimipramine