Sharing is caring: TMEM165 a Golgi calcium importer used by the lysosome

Austin K Murchison; Monther Abu-Remaileh

doi:10.1016/j.tibs.2024.05.006

Sharing is caring: TMEM165 a Golgi calcium importer used by the lysosome

Trends Biochem Sci. 2024 Aug;49(8):658-659. doi: 10.1016/j.tibs.2024.05.006. Epub 2024 May 29.

Authors

Austin K Murchison¹, Monther Abu-Remaileh²

Affiliations

¹ Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA; The Institute for Chemistry, Engineering, and Medicine for Human Health (Sarafan ChEM-H), Stanford University, Stanford, CA 94305, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA.
² Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA; The Institute for Chemistry, Engineering, and Medicine for Human Health (Sarafan ChEM-H), Stanford University, Stanford, CA 94305, USA. Electronic address: monther@stanford.edu.

PMID: 38816278
DOI: 10.1016/j.tibs.2024.05.006

Abstract

Calcium is a crucial second messenger in the cell that is stored in organelles including lysosomes. Proteins that facilitate calcium entry to the lysosome were unknown. A recent report by Zajac et al. identified TMEM165 as a proton-activated calcium importer on the lysosome, thus discovering a key player in subcellular calcium homeostasis.

Keywords: calcium; importer; ion homeostasis; lysosome; signaling.

MeSH terms

Animals
Calcium Channels / metabolism
Calcium* / metabolism
Golgi Apparatus* / metabolism
Humans
Lysosomes* / metabolism

Substances

Calcium
Calcium Channels