Discussion on "Bayesian meta-analysis of penetrance for cancer risk" by Thanthirige Lakshika M. Ruberu, Danielle Braun, Giovanni Parmigiani, and Swati Biswas

Biometrics. 2024 Mar 27;80(2):ujae043. doi: 10.1093/biomtc/ujae043.

Abstract

We congratulate the authors for the new meta-analysis model that accounts for different outcomes. We discuss the modeling choice and the Bayesian setting, specifically, we point out the connection between the Bayesian hierarchical model and a mixed-effect model formulation to subsequently discuss possible future method extensions.

Keywords: heterogeneity; mean value; multisource.

MeSH terms

  • Bayes Theorem*
  • Humans
  • Meta-Analysis as Topic*
  • Models, Statistical
  • Neoplasms*
  • Penetrance
  • Risk Assessment