Sessile adenoma of the gallbladder. Reappraisal of its importance as a precancerous lesion

Arch Pathol Lab Med. 1985 Jan;109(1):65-9.


Three hundred gallbladders from patients with cholelithiasis were examined under a dissection microscope. Sixteen (5%) were found to have what have been called sessile adenomas. They consisted of mixtures of hyperplastic lining epithelium and metaplastic mucous glands, and their interstitium often included smooth-muscle fibers. Small foci of moderately severe cellular atypism were present in 19% of the adenoma cases, but none had definitive evidence of malignancy. Carcinoembryonic antigen was demonstrated in hyperplastic lining epithelium with or without cellular atypism in 31% of the cases. Sessile adenomas most likely represent reactive overgrowth and therefore we prefer to term them hyperplastic polyps.

Publication types

  • Comparative Study

MeSH terms

  • Adenoma / metabolism
  • Adenoma / pathology*
  • Adult
  • Aged
  • Cholelithiasis / metabolism
  • Cholelithiasis / pathology
  • Gallbladder Neoplasms / metabolism
  • Gallbladder Neoplasms / pathology*
  • Histocytochemistry
  • Humans
  • Hyperplasia
  • Immunoenzyme Techniques
  • Metaplasia / pathology
  • Middle Aged
  • Precancerous Conditions*