The heavy chain of human histocompatibility antigen HLA-B7 contains an immunoglobulin-like region

Nature. 1979 Nov 15;282(5736):266-70. doi: 10.1038/282266a0.


The 88-residue fragment (ac-2) containing the second disulphide loop from HLA-B7 heavy chain is shown to have statistically significant homology with Ig constant domains, including both matches at invariant positions and conservative substitutions of structurally important residues. Thus, both the light chain (beta 2m) and a segment of the heavy chain of HLA antigens may be structurally and evolutionarily related to immunoglobulins.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Biological Evolution
  • HLA Antigens / genetics*
  • Humans
  • Hydrogen Bonding
  • Immunoglobulin Constant Regions / genetics*
  • Immunoglobulins / genetics*
  • Peptide Fragments
  • Protein Conformation
  • beta 2-Microglobulin / genetics


  • HLA Antigens
  • Immunoglobulin Constant Regions
  • Immunoglobulins
  • Peptide Fragments
  • beta 2-Microglobulin