Konjac glucomannan: A comprehensive review of its extraction, health benefits, and pharmaceutical applications

Carbohydr Polym. 2024 Sep 1:339:122266. doi: 10.1016/j.carbpol.2024.122266. Epub 2024 May 17.

Abstract

Konjac glucomannan (KG) is a dietary fiber hydrocolloid derived from Amorphophallus konjac tubers and is widely utilized as a food additive and dietary supplement. As a health-conscious choice, purified KG, along with konjac flour and KG-infused diets, have gained widespread acceptance in Asian and European markets. An overview of the chemical composition and structure of KG is given in this review, along with thorough explanations of the processes used in its extraction, production, and purification. KG has been shown to promote health by reducing glucose, cholesterol, triglyceride levels, and blood pressure, thereby offering significant weight loss advantages. Furthermore, this review delves into the extensive health benefits and pharmaceutical applications of KG and its derivatives, emphasizing its prebiotic, anti-inflammatory, and antitumor activities. This study highlights how these natural polysaccharides can positively influence health, underscoring their potential in various biomedical applications.

Keywords: Extraction; Glucomannan; Health benefits; Konjac; Pharmaceutical applications.

Publication types

  • Review

MeSH terms

  • Amorphophallus* / chemistry
  • Animals
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology
  • Dietary Fiber / analysis
  • Dietary Supplements
  • Humans
  • Mannans* / chemistry
  • Mannans* / isolation & purification
  • Prebiotics

Substances

  • Mannans
  • (1-6)-alpha-glucomannan
  • Dietary Fiber
  • Anti-Inflammatory Agents
  • Prebiotics
  • Antineoplastic Agents