Primary lymphoma of the central nervous system diagnosed by computed tomographic scan-directed needle biopsy with a frozen section immunoperoxidase technique

Neurosurgery. 1985 Jan;16(1):1-4.


Primary lymphoma of the central nervous system is an uncommon neoplasm that requires definitive diagnosis because it is potentially treatable. We report a case in which the diagnosis of lymphoma was unsuspected and was made by needle biopsy with computed tomographic scan direction. A frozen section immunoperoxidase technique demonstrated monoclonality. When combined with a compatible morphological appearance, this confirmed the diagnosis of lymphoma. This case demonstrates the importance of this immunochemical method in the rapid diagnosis of central nervous system lymphomas.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • B-Lymphocytes / pathology
  • Biopsy, Needle
  • Brain / pathology
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / pathology
  • Humans
  • Immunoenzyme Techniques
  • Lymphoma / diagnosis*
  • Lymphoma / pathology
  • Male
  • Tomography, X-Ray Computed