Statistical comparison of Pearl rates

Am J Obstet Gynecol. 1985 Mar 1;151(5):656-9. doi: 10.1016/0002-9378(85)90158-9.


Statistical procedures for hypothesis testing and interval estimation of the difference in a pair of Pearl rates are presented. The p value of the test statistic is evaluated exactly from the binomial distribution or approximately from the standard normal distribution. Interval estimation is provided by the test-based method of Miettinen. The procedures are applied to two published data sets, and the conceptual link between the Pearl rate and life-table methods is discussed.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Actuarial Analysis
  • Clinical Trials as Topic
  • Contraception*
  • Contraceptives, Oral
  • Female
  • Humans
  • Intrauterine Devices
  • Pregnancy*
  • Probability
  • Statistics as Topic*


  • Contraceptives, Oral