Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study

Amino Acids. 2024 Jun 6;56(1):39. doi: 10.1007/s00726-024-03398-2.

Abstract

Plasma total cysteine (tCys) is strongly associated with fat mass in humans. Mesna lowers plasma tCys in a dose-dependent manner, but it is not known whether it interferes with metabolism of other amino acids or protein. In this Phase-1 study, we show that a single dose of mesna administered at 400, 800, 1200 or 1600 mg to 6-7 individuals per dose only slightly affects amino acid profiles, with increases in plasma valine across dose levels. There were no effects of mesna on 3-methylhistidine, a marker of protein breakdown.

Keywords: 3-methylhistidine; Amino acid profile; Mesna; Obesity; Overweight; Total cysteine.

Publication types

  • Clinical Trial, Phase I
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Amino Acids / blood
  • Cysteine / chemistry
  • Dose-Response Relationship, Drug*
  • Female
  • Humans
  • Male
  • Methylhistidines*
  • Middle Aged

Substances

  • Methylhistidines
  • 3-methylhistidine
  • Amino Acids
  • Cysteine