Redefining intestinal stemness: The emergence of a new ISC population

Mei-Lan Li; Kaelyn Sumigray

doi:10.1016/j.cell.2024.04.021

Redefining intestinal stemness: The emergence of a new ISC population

Cell. 2024 Jun 6;187(12):2900-2902. doi: 10.1016/j.cell.2024.04.021.

Authors

Mei-Lan Li¹, Kaelyn Sumigray²

Affiliations

¹ Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA.
² Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA; Yale Stem Cell Center, Yale School of Medicine, New Haven, CT 06510, USA; Yale Cancer Center, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: kaelyn.sumigray@yale.edu.

PMID: 38848673
DOI: 10.1016/j.cell.2024.04.021

Abstract

In tissue homeostasis, intestinal stem cells (ISCs) undergo continuous self-renewal to sustain rapid cellular turnover. In this issue of Cell, Capdevila et al.¹ and Malagola, Vasciaveo, et al.² identify a new ISC population in the upper crypt that can generate Lgr5⁺ stem cells during homeostasis.

MeSH terms

Animals
Cell Differentiation
Homeostasis
Humans
Intestinal Mucosa / cytology
Intestinal Mucosa / metabolism
Intestines* / cytology
Mice
Receptors, G-Protein-Coupled / metabolism
Stem Cells* / cytology
Stem Cells* / metabolism

Substances

Receptors, G-Protein-Coupled