A polysubstituted cyclopentane and two glycerol esters from the engineered strain Streptomyces sp. S35-LAL1

Nat Prod Res. 2024 Jun 9:1-6. doi: 10.1080/14786419.2024.2364932. Online ahead of print.


Activation of silencing gene clusters is an important way to discover structurally novel compounds. In this study, three undescribed compounds were obtained from an engineered strain of Streptomyces sp. S35-LAL1. They include a polysubstituted cyclopentane with an unprecedented 10-carbon skeleton (1) and two glycerol esters (2 and 3). The structures of compounds 1-3 were elucidated through analysis of their spectroscopic data including 1D, 2D NMR, optical rotation, and electronic circular dichroism (ECD).

Keywords: Streptomyces sp. S35; electronic circular dichroism; glycerol ester; polysubstituted cyclopentane.