Prader-Willi Syndrome: The More We Know, the Less We Know

Mo Med. 2024 May-Jun;121(3):235-241.


Prader-Willi syndrome (PWS) is a complex genetic neurodevelopmental disorder with multisystem impact and a unique behavior profile that evolves over the life span. Beyond the primary care needs of all children and adults, the unique medical concerns and management needs of those with PWS are best served in a multidisciplinary academic center. Our PWS center has provided care for individuals with PWS and their families since 1981. Our growth hormone studies contributed to growth hormone supplementation becoming standard of care in this country. Here, in collaboration with the primary care provider, early childhood intervention programs, schools and local parent organizations, solid, patient-centered care for affected individuals and their families can be provided across the life-span. The purpose of this article is to provide a brief overview of PWS and the attendant medical and behavior management challenges attendant to the disorder.

Publication types

  • Review

MeSH terms

  • Child
  • Human Growth Hormone / therapeutic use
  • Humans
  • Prader-Willi Syndrome* / diagnosis
  • Prader-Willi Syndrome* / genetics
  • Prader-Willi Syndrome* / therapy


  • Human Growth Hormone