Two challenging cases of anti-MDA-5 dermatomyositis with rapidly progressive interstitial lung disease

Kathryn Biddle; Elif Agaoglu; Geoffrey Brent; John Adam; Rachel Nockels; Adam Loveridge; Farid Bazari; Janakan Natkunarajah; Israa Al-Shakarchi

doi:10.1093/omcr/omae061

Two challenging cases of anti-MDA-5 dermatomyositis with rapidly progressive interstitial lung disease

Oxf Med Case Reports. 2024 Jun 7;2024(6):omae061. doi: 10.1093/omcr/omae061. eCollection 2024 Jun.

Authors

Kathryn Biddle^{1

2}, Elif Agaoglu³, Geoffrey Brent⁴, John Adam⁵, Rachel Nockels⁵, Adam Loveridge³, Farid Bazari³, Janakan Natkunarajah⁴, Israa Al-Shakarchi²

Affiliations

¹ St George's University of London, Infection and Immunity, Cranmer Terrace, London, SW17 0RE, UK.
² Kingston Hospital NHS Foundation Trust, Rheumatology, Kingston upon Thames, KT2 7QB, UK.
³ Kingston Hospital NHS Foundation Trust, Respiratory, Kingston upon Thames, KT2 7QB, UK.
⁴ Kingston Hospital NHS Foundation Trust, Dermatology, Kingston upon Thames, KT2 7QB, UK.
⁵ Kingston Hospital NHS Foundation Trust, General Medicine, Kingston upon Thames, KT2 7QB, UK.

Abstract

Anti-MDA-5 dermatomyositis (DM) is a subtype of idiopathic inflammatory myopathy, commonly presenting as clinically amyopathic dermatomyositis. It is associated with rapidly progressive interstitial lung disease and a poor prognosis. Here, we present two cases of anti-MDA-5 DM and discuss the challenges associated with timely diagnosis, and the importance of early and aggressive treatment.

Keywords: critical care medicine; dermatology; immunology; respiratory disorders; rheumatology.

Publication types

Case Reports