Further support for inhibition of endogenous insulin secretion by exogenous insulin

Exp Clin Endocrinol. 1985 Feb;85(1):75-80. doi: 10.1055/s-0029-1210422.


In order to investigate whether or not insulin exerts any influence on endogenous insulin secretion, 6 non-obese healthy volunteers were connected to the artificial beta-cell (BIOSTATOR) for 16 hours. After an overnight fast 0.4 U of intermediate acting insulin (Monotard MC/NOVO INDUSTRIES) per kg body weight were injected subcutaneously. The computer program was set to maintain steady-state plasma glucose concentrations at fasting levels by a variable glucose infusion. This approach is able to prevent completely hypoglycemic episodes. Endogenous insulin secretion was evaluated by measuring plasma C-peptide concentrations. Whereas plasma insulin levels increased markedly in response to insulin injection at the same time C-peptide levels declined correspondingly, indicating an inhibition of insulin secretion. Thus, our results provided further support for a negative feedback regulation of insulin secretion by insulin itself.

MeSH terms

  • Adult
  • Blood Glucose / analysis
  • C-Peptide / blood
  • Feedback
  • Glucose
  • Humans
  • Hypoglycemia / prevention & control
  • Insulin / blood
  • Insulin / metabolism*
  • Insulin / pharmacology*
  • Insulin Antagonists / pharmacology*
  • Insulin Secretion


  • Blood Glucose
  • C-Peptide
  • Insulin
  • Insulin Antagonists
  • Glucose