Beta-cell reserve capacity in chronic pancreatitis

Hepatogastroenterology. 1985 Feb;32(1):27-30.

Abstract

The degree of correlation between exocrine pancreatic function and endocrine secretory capacity was examined in 13 chronic pancreatitis patients with secondary diabetes mellitus, 8 chronic pancreatitis patients without diabetes, and 11 healthy subjects. The two parameters were studied under maximal stimulation (volume-corrected secretin-pancreozym test and glucose-tolbutamide-glucagon provocation, respectively). A close, linear correlation was found between all endocrine variables and pancreatic acinar function (e.g. rs = 0.77 for chymotrypsin output and C-peptide release; p less than 0.0001). The correlation was less strong with pancreatic bicarbonate output (e.g. rs = 0.49 for C-peptide release; p less than 0.05). In our patients, secondary overt diabetes occurred in chronic pancreatitis when protease outputs were, on an average, reduced to about 10% of the mean maximal protease output of normal subjects.

MeSH terms

  • Adult
  • C-Peptide / metabolism
  • Chronic Disease
  • Chymotrypsin / metabolism
  • Diabetes Mellitus, Type 2 / etiology*
  • Female
  • Humans
  • Insulin / metabolism
  • Insulin Secretion
  • Islets of Langerhans / metabolism*
  • Male
  • Pancreatic Function Tests
  • Pancreatic Hormones / metabolism
  • Pancreatitis / complications
  • Pancreatitis / physiopathology*

Substances

  • C-Peptide
  • Insulin
  • Pancreatic Hormones
  • Chymotrypsin