DNMT3A gates IFN-induced MPN HSC exhaustion

Blood. 2024 Jun 13;143(24):2445-2446. doi: 10.1182/blood.2024024448.
No abstract available

Publication types

  • Editorial
  • Comment

MeSH terms

  • Animals
  • DNA (Cytosine-5-)-Methyltransferases* / genetics
  • DNA (Cytosine-5-)-Methyltransferases* / metabolism
  • DNA Methyltransferase 3A*
  • Hematopoietic Stem Cells / drug effects
  • Hematopoietic Stem Cells / metabolism
  • Hematopoietic Stem Cells / pathology
  • Humans
  • Interferons / metabolism
  • Mice
  • Myeloproliferative Disorders / metabolism
  • Myeloproliferative Disorders / pathology

Substances

  • DNA (Cytosine-5-)-Methyltransferases
  • DNA Methyltransferase 3A
  • DNMT3A protein, human
  • Interferons