Prevalence and Causes of Vitamin D Deficiency in a Cohort of Greek HIV-Infected Individuals: A Prospective, Single Center, Observational Study

Theodoros Androutsakos; Marianna Politou; Sofia Boti; Theodoros Pittaras; Athanasios Kontos; Theodore Kordossis; Abraham Pouliakis; George Panayiotakopoulos

doi:10.2174/011570162X302844240605104855

Prevalence and Causes of Vitamin D Deficiency in a Cohort of Greek HIV-Infected Individuals: A Prospective, Single Center, Observational Study

Curr HIV Res. 2024;22(4):240-248. doi: 10.2174/011570162X302844240605104855.

Authors

Theodoros Androutsakos¹, Marianna Politou², Sofia Boti¹, Theodoros Pittaras², Athanasios Kontos¹, Theodore Kordossis¹, Abraham Pouliakis³, George Panayiotakopoulos⁴

Affiliations

¹ Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
² Hematology Laboratory-Blood Bank at the Aretaieion Hospital, Second Department of Hematology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
³ Second Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
⁴ Department of Pharmacology, Medical School, University of Patras, Patras, Greece.

PMID: 38874038
DOI: 10.2174/011570162X302844240605104855

Abstract

Background: Vitamin D deficiency and/or insufficiency (hypovitaminosis D) has been associated with several disorders including autoimmune diseases, like type 1 diabetes mellitus; cardiovascular diseases; neoplasms; obesity; insulin resistance, and type 2 diabetes mellitus. This problem is common in southern European countries, especially in elderly and institutionalized persons. In HIV-infected individuals, hypovitaminosis D has been correlated with various complications like tuberculosis, hyperparathyroidism, bone mass loss, premature atherosclerosis, and systemic arterial hypertension, deterioration of immune function, progression of the disease and overall mortality.

Objective: The objective of this study was to examine the prevalence and causes of hypovitaminosis D in a cohort of Greek HIV-infected patients, as well as possible complications associated with it.

Methods: All patients attending our HIV unit for a period of 5 months were included in this study. Vitamin D status, medical anamnes, and laboratory tests were obtained at baseline; patients were followed for 3 years and HIV-related complications were noted. No patient received vitamin D supplementation during the follow-up period.

Results: Hypovitaminosis D was common, with 83.7% of the patients showing levels below 30 ng/dl and 55.4% below 20 ng/dl. After multivariable analysis, age and duration of treatment were the only significant factors for low vitamin D levels. During follow-up, 26 patients exhibited a total of 34 HIV-related complications, the most common being pneumonocystis jiroveci pneumonia (PCP). Hypovitaminosis D showed a positive correlation with overall complications, PCP as well as wasting syndrome.

Conclusion: Overall, our study shows that hypovitaminosis D is common in HIV-infected individuals and should probably be treated as soon as possible to protect these patients from serious HIVrelated complications like PCP or wasting syndrome.

Keywords: HIV; hypovitaminosis D; immunodeficiency.; pneumocystis jiroveci pneumonia; vitamin D; wasting syndrome.

Publication types

Observational Study

MeSH terms

Adult
Aged
Female
Greece / epidemiology
HIV Infections* / complications
HIV Infections* / epidemiology
Humans
Male
Middle Aged
Prevalence
Prospective Studies
Vitamin D / blood
Vitamin D Deficiency* / complications
Vitamin D Deficiency* / epidemiology

Substances

Vitamin D