Histological preservation and ultrastructure of alveolar surfactant

Annu Rev Physiol. 1985;47:753-63. doi: 10.1146/annurev.ph.47.030185.003541.


We have discussed the three-dimensional structure of lamellar bodies as visible intracellular storage sites of surfactant. Among the intraalveolar structures, tubular myelin, a liquid crystal, represents a large aggregate of surfactant lipids and proteins of still-unclear significance. Elaborate fixation methods permit visualization in situ of localized pools of fluid that sometimes extend laterally, covering small areas of the alveolar surface.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Products*
  • Freeze Fracturing
  • Humans
  • Microscopy, Electron
  • Myelin Sheath
  • Organoids / analysis
  • Organoids / ultrastructure
  • Proteins*
  • Pulmonary Alveoli / analysis
  • Pulmonary Alveoli / ultrastructure*
  • Pulmonary Surfactants / analysis*


  • Biological Products
  • Proteins
  • Pulmonary Surfactants
  • tubular myelin