Artificial intelligence-based morphologic classification and molecular characterization of neuroblastic tumors from digital histopathology

Res Sq [Preprint]. 2024 Jun 4:rs.3.rs-4396782. doi: 10.21203/rs.3.rs-4396782/v1.

Abstract

A deep learning model using attention-based multiple instance learning (aMIL) and self-supervised learning (SSL) was developed to perform pathologic classification of neuroblastic tumors and assess MYCN-amplification status using H&E-stained whole slide digital images. The model demonstrated strong performance in identifying diagnostic category, grade, mitosis-karyorrhexis index (MKI), and MYCN-amplification on an external test dataset. This AI-based approach establishes a valuable tool for automating diagnosis and precise classification of neuroblastoma tumors.

Publication types

  • Preprint