Peptide histidine methionine (PHM) and the human male genitalia

Neuropeptides. 1985 Apr;6(2):133-42. doi: 10.1016/0143-4179(85)90104-0.


Peptide histidine methionine-like immunoreactivity (PHM-IR) has been demonstrated to be present in the human penis both by radioimmunoassay and immunohistochemistry with particularly high levels in the corpus cavernosum and vas deferens. In the cavernosa, PHM-IR has been localised entirely, in nerves around arteries. High performance liquid chromatography indicated that this PHM-IR co-eluted with synthetic PHM but not porcine PHI. The presence of PHM-IR in the penis suggests that this neuropeptide may play a functional role in penile function.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fluorescent Antibody Technique
  • Genitalia, Male / analysis*
  • Genitalia, Male / metabolism
  • Humans
  • Male
  • Penis / analysis
  • Radioimmunoassay
  • Vasoactive Intestinal Peptide / metabolism


  • Vasoactive Intestinal Peptide