[Buflomedil and nicergoline in the targeted treatment of acute cerebral ischemia. Randomized comparative double blind study]

Minerva Med. 1985 May 19;76(21):1005-18.
[Article in Italian]


Acute cerebral ischaemia may take considerable advantages of an adequate intensive therapy associated with a specific treatment of cerebral oedemas, especially in terms of mortality-rate reduction. Moreover, target treatment of acute cerebral ischaemia may produce excellent results in severe cases selected by means of EEG-chronospectrography. Double-blind, randomized comparison between nicergolin and buflomedil especialls showed that the latter reduces mortality three times as much as nicergolin, and leads to a 200% increment in the complete recovery of the "functio laesa", limited to those cases, which showed an appreciable improvement following EEG-chronospectrographical survey.

Publication types

  • Clinical Trial
  • Comparative Study
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Acute Disease
  • Aged
  • Brain Ischemia / drug therapy*
  • Cerebrovascular Circulation
  • Clinical Trials as Topic
  • Double-Blind Method
  • Drug Evaluation
  • Electroencephalography
  • Ergolines / therapeutic use*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nicergoline / pharmacology
  • Nicergoline / therapeutic use*
  • Pyrrolidines / pharmacology
  • Pyrrolidines / therapeutic use*
  • Random Allocation


  • Ergolines
  • Pyrrolidines
  • Nicergoline
  • buflomedil