Treatment of infantile colic with surface active substance (simethicone)

Acta Paediatr Scand. 1985 May;74(3):446-50. doi: 10.1111/j.1651-2227.1985.tb11001.x.


The effect of Simethicone on "colicky" (n = 27) infants was tested in a double-blind cross-over study. Three different parameters were used to measure the efficiency of the treatment: interviews, 24-hour records and behavioral observations. No effects of Simethicone on the symptoms of infantile colic could be demonstrated. However, 67% of the infants improved during the treatment, which could be ascribed to a high-grade placebo-effect.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Clinical Trials as Topic
  • Colic / drug therapy*
  • Double-Blind Method
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Silicones / therapeutic use*
  • Simethicone / therapeutic use*
  • Surface-Active Agents / therapeutic use*


  • Silicones
  • Surface-Active Agents
  • Simethicone