Diagnostic accuracy of high-frequency ultrasound for cutaneous neoplasms: a narrative review of the literature

Arch Dermatol Res. 2024 Jun 21;316(7):419. doi: 10.1007/s00403-024-03179-7.


High-frequency ultrasound has been used to visualize depth and vascularization of cutaneous neoplasms, but little has been synthesized as a review for a robust level of evidence about the diagnostic accuracy of high-frequency ultrasound in dermatology. A narrative review of the PubMed database was performed to establish the correlation between ultrasound findings and histopathologic/dermoscopic findings for cutaneous neoplasms. Articles were divided into the following four categories: melanocytic, keratinocytic/epidermal, appendageal, and soft tissue/neural neoplasms. Review of the literature revealed that ultrasound findings and histopathology findings were strongly correlated regarding the depth of a cutaneous neoplasm. Morphological characteristics were correlated primarily in soft tissue/neural neoplasms. Overall, there is a paucity of literature on the correlation between high-frequency ultrasound and histopathology of cutaneous neoplasms. Further studies are needed to investigate this correlation in various dermatologic conditions.

Keywords: Cutaneous neoplasm; General dermatology; Medical dermatology; Oncology; Pathology; Ultrasound.

Publication types

  • Review

MeSH terms

  • Dermoscopy / methods
  • Humans
  • Melanoma / diagnosis
  • Melanoma / diagnostic imaging
  • Melanoma / pathology
  • Skin / diagnostic imaging
  • Skin / pathology
  • Skin Neoplasms* / diagnosis
  • Skin Neoplasms* / diagnostic imaging
  • Skin Neoplasms* / pathology
  • Ultrasonography* / methods