Synthesis and characterization of new acid-functionalized porphyrins displaying antimicrobial activity against gram positive bacteria, yeasts and filamentous fungi with or without ultra-high irradiance

Bioorg Med Chem. 2024 Jul 15:109:117810. doi: 10.1016/j.bmc.2024.117810. Epub 2024 Jun 13.

Abstract

The antimicrobial activity of new acid-functionalized porphyrins, with or without ultra-high irradiance, was investigated. Antibacterial efficacy was evaluated against Staphylococcus aureus (methicillin-resistant or methicillin-sensitive strains) and antifungal efficacy was evaluated against the yeast Candida albicans and the filamentous fungi Aspergillus fumigatus. Overall, the porphyrins tested are more effective against S. aureus. The best results were obtained with zinc diacid porphyrins 4 and 5 after only 3 min of ultra-high irradiation (500 mW/cm2, 405 nm), demonstrating that acid-functionalized porphyrins are promising as novel antimicrobial drugs for surface disinfection.

Keywords: Antimicrobial agent; Photosensitizer; Porphyrin; Ultra-high irradiation.

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Antifungal Agents* / chemical synthesis
  • Antifungal Agents* / chemistry
  • Antifungal Agents* / pharmacology
  • Aspergillus fumigatus* / drug effects
  • Candida albicans* / drug effects
  • Dose-Response Relationship, Drug
  • Fungi / drug effects
  • Gram-Positive Bacteria / drug effects
  • Microbial Sensitivity Tests*
  • Molecular Structure
  • Porphyrins* / chemical synthesis
  • Porphyrins* / chemistry
  • Porphyrins* / pharmacology
  • Staphylococcus aureus / drug effects
  • Structure-Activity Relationship

Substances

  • Porphyrins
  • Antifungal Agents
  • Anti-Bacterial Agents