Crystal structure of MAGEA4 MHD-RAD18 R6BD reveals a flipped binding mode compared to AlphaFold2 prediction
EMBO J. 2024 Jul;43(14):2835-2839.
doi: 10.1038/s44318-024-00140-2.
Epub 2024 Jun 21.
- PMID: 38907034
- PMCID: PMC11251181
- DOI: 10.1038/s44318-024-00140-2
Abstract
Publication types
- Letter
- Comment
MeSH terms
- Binding Sites
- Crystallography, X-Ray
- DNA-Binding Proteins / chemistry
- DNA-Binding Proteins / metabolism
- Humans
- Models, Molecular
- Neoplasm Proteins / chemistry
- Neoplasm Proteins / genetics
- Neoplasm Proteins / metabolism
- Protein Binding*
- Protein Conformation
Substances
- DNA-Binding Proteins
- Neoplasm Proteins
Grants and funding
- P30 ES010126/ES/NIEHS NIH HHS/United States
- R35 GM125005/GM/NIGMS NIH HHS/United States
- CA279034/HHS | NIH | National Cancer Institute (NCI)
- CA229530/HHS | NIH | National Cancer Institute (NCI)
- GM125005/HHS | NIH | National Institute of General Medical Sciences (NIGMS)
- R01 CA279034/CA/NCI NIH HHS/United States
- R01 CA229530/CA/NCI NIH HHS/United States
- P30 GM124165/GM/NIGMS NIH HHS/United States