The use of methotrexate in rheumatoid arthritis

Drug Intell Clin Pharm. 1985 May;19(5):349-58. doi: 10.1177/106002808501900503.


The use of methotrexate in rheumatoid arthritis is reviewed. Methotrexate, a folic acid antagonist, is sometimes employed in an attempt to symptomatically control patients whose disease does not respond adequately to conventional therapies. Systemic administration of 7.5-15 mg/wk in a "pulse" fashion appears to be effective without precipitating severe adverse effects. However, concern over potentially serious side effects and a lack of well-controlled clinical trials have limited its use to severe, refractory disease. Further studies are needed before its role in rheumatoid arthritis can justifiably be expanded.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / pathology
  • Cell Division / drug effects
  • Humans
  • Injections, Intra-Articular
  • Methotrexate / administration & dosage
  • Methotrexate / adverse effects
  • Methotrexate / pharmacology
  • Methotrexate / therapeutic use*


  • Methotrexate