Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons

Andreas Papassotiropoulos; Dominique J-F de Quervain

doi:10.1126/scisignal.adp5354

Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons

Sci Signal. 2024 Jun 25;17(842):eadp5354. doi: 10.1126/scisignal.adp5354. Epub 2024 Jun 25.

Authors

Andreas Papassotiropoulos^{1

2

3}, Dominique J-F de Quervain^{2

3

4}

Affiliations

¹ Division of Molecular Neuroscience, Department of Biomedicine, University of Basel, CH-4055 Basel, Switzerland.
² Research Cluster Molecular and Cognitive Neurosciences, University of Basel, CH-4055 Basel, Switzerland.
³ Psychiatric University Clinics, University of Basel, CH-4055 Basel, Switzerland.
⁴ Division of Cognitive Neuroscience, Department of Biomedicine, University of Basel, CH-4055 Basel, Switzerland.

PMID: 38917220
DOI: 10.1126/scisignal.adp5354

Abstract

WWC1 is a scaffolding protein in the evolutionarily conserved Hippo signaling network and is genetically linked to human memory and synaptic plasticity. In the archives of Science Signaling, Stepan et al. demonstrate the translational potential of modulating WWC1 through pharmacological inhibition of Hippo-pathway kinases to enhance cognition.

Publication types

Review

MeSH terms

Animals
Humans
Intracellular Signaling Peptides and Proteins / genetics
Intracellular Signaling Peptides and Proteins / metabolism
Memory* / physiology
Neuronal Plasticity* / physiology
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism
Proteins / genetics
Proteins / metabolism
Signal Transduction*

Substances

WWC1 protein, human
Intracellular Signaling Peptides and Proteins
Protein Serine-Threonine Kinases
Proteins