Crosstalk between CXCL12/CXCR4/ACKR3 and the STAT3 Pathway

Cells. 2024 Jun 13;13(12):1027. doi: 10.3390/cells13121027.

Abstract

The reciprocal modulation between the CXCL12/CXCR4/ACKR3 axis and the STAT3 signaling pathway plays a crucial role in the progression of various diseases and neoplasms. Activation of the CXCL12/CXCR4/ACKR3 axis triggers the STAT3 pathway through multiple mechanisms, while the STAT3 pathway also regulates the expression of CXCL12. This review offers a thorough and systematic analysis of the reciprocal regulatory mechanisms between the CXCL12/CXCR4/ACKR3 signaling axis and the STAT3 signaling pathway in the context of diseases, particularly tumors. It explores the potential clinical applications in tumor treatment, highlighting possible therapeutic targets and novel strategies for targeted tumor therapy.

Keywords: CXCL12/CXCR4/ACKR3 axis; IL6; JAK2; STAT3 signaling pathway; targeted therapy.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chemokine CXCL12* / metabolism
  • Humans
  • Neoplasms* / metabolism
  • Neoplasms* / pathology
  • Receptors, CXCR / genetics
  • Receptors, CXCR / metabolism
  • Receptors, CXCR4* / metabolism
  • STAT3 Transcription Factor* / metabolism
  • Signal Transduction*

Substances

  • STAT3 Transcription Factor
  • Receptors, CXCR4
  • Chemokine CXCL12
  • ACKR3 protein, human
  • Receptors, CXCR
  • CXCL12 protein, human
  • STAT3 protein, human