A new form of amyloid protein associated with chronic hemodialysis was identified as beta 2-microglobulin

Biochem Biophys Res Commun. 1985 Jun 28;129(3):701-6. doi: 10.1016/0006-291x(85)91948-5.


Amyloid fibrils were isolated from amyloid-laden tissue obtained from a chronic hemodialysis patient with carpal tunnel syndrome. After solubilization in guanidine HCl, a significant amount of the protein was located in a homogeneous low molecular weight fraction. The protein was found to be identical to beta 2-microglobulin, with regard to its molecular weight of 11,000, amino acid composition and 16 amino-terminal amino acids: Ile-Gln-Arg-Thr-Pro-Lys-Ile-Gln-Val-Tyr-Ser-Arg-His-Pro-Ala-Glu-. These results demonstrate that the amyloid associated with chronic hemodialysis contains as major component a new form of amyloid fibril protein that is homologous to beta 2-microglobulin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Amino Acids / analysis
  • Amyloidosis / etiology*
  • Carpal Tunnel Syndrome / etiology
  • Carpal Tunnel Syndrome / surgery
  • Chromatography, High Pressure Liquid
  • Female
  • Glomerulonephritis / complications
  • Humans
  • Kidney Failure, Chronic / etiology
  • Kidney Failure, Chronic / therapy
  • Middle Aged
  • Molecular Weight
  • Renal Dialysis / adverse effects*
  • beta 2-Microglobulin / analysis*


  • Amino Acids
  • beta 2-Microglobulin