Effect of oral N-acetylcysteine on mucus clearance

Br J Dis Chest. 1985 Jul;79(3):262-6.


Oral N-acetylcysteine has been advocated as a mucolytic agent for use in chronic bronchitis. We have investigated the effects of regular use of this drug at a dose of 200 mg thrice daily for 4 weeks in nine patients with chronic bronchitis on lung function, lung mucociliary clearance and sputum viscosity in a controlled, double-blind, crossover study. No significant differences were found in lung function, mucociliary clearance curves or sputum viscosity following treatment with N-acetylcysteine compared to control or placebo measurements.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcysteine / administration & dosage
  • Acetylcysteine / therapeutic use*
  • Administration, Oral
  • Aged
  • Bronchitis / drug therapy*
  • Bronchitis / physiopathology
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Humans
  • Lung / drug effects
  • Lung / physiopathology
  • Male
  • Mucus / drug effects
  • Respiratory Function Tests


  • Acetylcysteine