Neuronal senescence may drive brain aging

Science. 2024 Jun 28;384(6703):1404-1406. doi: 10.1126/science.adi3450. Epub 2024 Jun 27.

Authors

Joseph R Herdy¹, Jerome Mertens², Fred H Gage¹

Affiliations

¹ Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA.
² Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.

Abstract

Senescence of postmitotic neurons presents challenges and opportunities to modify brain aging.

MeSH terms

Aging* / physiology
Animals
Brain* / physiology
Cellular Senescence*
Humans
Mice
Neurons* / physiology

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