Comparison of single-dose vs one-week course of metronidazole for symptomatic bacterial vaginosis

JAMA. 1985 Aug 23-30;254(8):1046-9.

Abstract

In a prospective, single-blind, randomized study, a single 2-g dose of metronidazole was compared with a seven-day course of 500 mg given twice daily in the treatment of symptomatic vaginal discharge associated with Gardnerella vaginalis. Based on resolution of symptoms and on cultures negative for G vaginalis, 86% (40/46) of women treated with the single dose and 97% (35/36) of women treated with the seven-day course were considered cured at seven to ten days after treatment. Evaluation at 21 days after treatment, however, indicated that only 46% (16/34) of patients treated with the single 2-g dose were considered cured compared with 86% (26/30) of those treated with the seven-day course. Treatment of sexual contacts did not significantly improve cure rates in either group.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Bacteriological Techniques
  • Drug Administration Schedule
  • Female
  • Gardnerella vaginalis / isolation & purification
  • Haemophilus Infections / drug therapy*
  • Humans
  • Male
  • Metronidazole / administration & dosage*
  • Metronidazole / adverse effects
  • Middle Aged
  • Random Allocation
  • Sexual Behavior
  • Vaginitis / drug therapy*
  • Vaginitis / microbiology

Substances

  • Metronidazole