Neural tissue grafts and repair of the injured spinal cord

Neuropathol Appl Neurobiol. 1985 Mar-Apr;11(2):81-104. doi: 10.1111/j.1365-2990.1985.tb00007.x.


Neural tissue grafting presently stands as one of the more intriguing experimental strategies being applied to the problem of spinal cord regeneration. The following annotation presents an overview of recent investigations which have shown: that peripheral nerve grafts can stimulate axonal outgrowth in many descending and ascending fibre populations of the injured spinal cord and that central nervous system (CNS) implants, derived from segmental and supraspinal levels of the embryonic neuraxis, may likewise have the potential for promoting repair of damaged intraspinal neural circuitries in adult and neonatal recipients.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Animals, Newborn
  • Brain Stem / embryology
  • Brain Stem / transplantation
  • Central Nervous System / transplantation
  • Cerebral Cortex / embryology
  • Cerebral Cortex / transplantation
  • Graft Survival
  • Nerve Tissue / transplantation*
  • Peripheral Nerves / transplantation
  • Rats
  • Spinal Cord / embryology
  • Spinal Cord / physiopathology
  • Spinal Cord Injuries / physiopathology
  • Spinal Cord Injuries / surgery*
  • Wound Healing